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pentobarbital will decrease the extent or result of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital boosts effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor. Coadministration of ifosfamide with CYP2B6 inducers may perhaps maximize metabolism of ifosfamide